Press Release: Novartis receives third FDA -2-

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care cost containment, including government, payor and general public pricing and reimbursement pressures and requirements for increased pricing transparency; our ability to obtain or maintain proprietary intellectual property protection; the particular prescribing preferences of physicians and patients; general political, economic and business conditions, including the effects of and efforts to mitigate pandemic diseases; safety, quality, data integrity or manufacturing issues; potential or actual data security and data privacy breaches, or disruptions of our information technology systems, and other risks and factors referred to in Novartis AG's current Form 20-F on file with the US Securities and Exchange Commission. Novartis is providing the information in this press release as of this date and does not undertake any obligation to update any forward-looking statements contained in this press release as a result of new information, future events or otherwise.

About Novartis

Novartis is an innovative medicines company. Every day, we work to reimagine medicine to improve and extend people's lives so that patients, healthcare professionals and societies are empowered in the face of serious disease. Our medicines reach nearly 300 million people worldwide.

Reimagine medicine with us: Visit us at https://www.novartis.com/ https://www.novartis.com and connect with us on https://www.linkedin.com/company/novartis/ LinkedIn, https://www.facebook.com/novartis/ Facebook, https://twitter.com/Novartis X/Twitter and https://instagram.com/novartis?igshid=MzRlODBiNWFlZA==__;!!N3hqHg43uw!pjp8z253J5NjaOYrW65UbAAlHeHRdQ-w0m4ezZxEQEl0ptafXN2M99VRIk39pf49PAc8NbK93Pxp3uaSBQkAf8oEnzWXG8Sk$ Instagram.

References

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https://www.ncbi.nlm.nih.gov/books/NBK1425/. Accessed February 2025.

3. Schena FP, Esposito P, Rossini M. A Narrative Review on C3

Glomerulopathy: A Rare Renal Disease. Int J Mol Sci. 2020;21(2):525.

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Glomerulopathy: A Complement-Mediated Disease. Nephron.

2020;144(6):272-280.

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2025.

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iptacopan in patients with C3 glomerulopathy: 12-Month results from the

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(ASN) Kidney Week 2024; October 23-27, 2024; San Diego, CA.

11. Novartis. Novartis oral Fabhalta(R) (iptacopan) receives positive CHMP

opinion for the treatment of adults living with C3 glomerulopathy (C3G).

Available from:

https://www.novartis.com/news/media-releases/novartis-oral-fabhalta-iptacopan-receives-positive-chmp-opinion-treatment-adults-living-c3-glomerulopathy-c3g.

Accessed March 2025.

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With C3 Glomerulopathy. (APPEAR-C3G). Available from:

https://clinicaltrials.gov/study/NCT04817618. Accessed February 2025.

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(END) Dow Jones Newswires

March 20, 2025 19:11 ET (23:11 GMT)