|
26.11.2024 07:00:00
|
Roche reports update on Phase III SKYSCRAPER-01 study results
Basel, 26 November 2024 - Roche (SIX: RO, ROG; OTCQX: RHHBY) reports an update on the phase III SKYSCRAPER-01 study, evaluating tiragolumab combined with Tecentriq® (atezolizumab) compared to Tecentriq alone for patients with PD-L1-high, locally advanced or metastatic non-small cell lung cancer (NSCLC).
SKYSCRAPER-01 is a global phase III, randomised, double-blind study evaluating tiragolumab plus Tecentriq compared to Tecentriq alone in 534 patients with PD-L1-high previously untreated, locally advanced unresectable or metastatic NSCLC. Patients were randomised 1:1 to receive either tiragolumab plus Tecentriq or placebo plus Tecentriq, until disease progression, loss of clinical benefit, or unacceptable toxicity. The study did not reach the primary endpoint of overall survival at the final analysis. The overall safety profile observed remained consistent with longer follow-up, and no new safety signals were identified. The detailed data will be presented at a medical meeting in 2025.
Roche continuously reviews its study programmes to determine if any adjustments are necessary for the purposes of ongoing research. Roche will apply the same principles to this programme, with additional data from phase III studies across different settings or tumour types anticipated next year.
About tiragolumab
Tiragolumab is an investigational immune checkpoint inhibitor with an intact Fc region. Tiragolumab selectively binds to TIGIT, a novel inhibitory immune checkpoint which suppresses the immune response to cancer.1
About Tecentriq
Tecentriq is a monoclonal antibody designed to bind with a protein called PD-L1. Tecentriq is designed to bind to PD-L1 expressed on tumour cells and tumour-infiltrating immune cells, blocking its interactions with both PD-1 and B7.1 receptors. By inhibiting PD-L1, Tecentriq may enable the re-activation of T cells. Tecentriq may also affect normal cells.
About Roche
Founded in 1896 in Basel, Switzerland, as one of the first industrial manufacturers of branded medicines, Roche has grown into the world’s largest biotechnology company and the global leader in in-vitro diagnostics. The company pursues scientific excellence to discover and develop medicines and diagnostics for improving and saving the lives of people around the world. We are a pioneer in personalised healthcare and want to further transform how healthcare is delivered to have an even greater impact. To provide the best care for each person we partner with many stakeholders and combine our strengths in Diagnostics and Pharma with data insights from the clinical practice.
For over 125 years, sustainability has been an integral part of Roche’s business. As a science-driven company, our greatest contribution to society is developing innovative medicines and diagnostics that help people live healthier lives. Roche is committed to the Science Based Targets initiative and the Sustainable Markets Initiative to achieve net zero by 2045.
Genentech, in the United States, is a wholly owned member of the Roche Group. Roche is the majority shareholder in Chugai Pharmaceutical, Japan.
For more information, please visit www.roche.com.
All trademarks used or mentioned in this release are protected by law.
Roche Global Media Relations
Phone: +41 61 688 8888 / e-mail: media.relations@roche.com
|
Hans Trees, PhD Phone: +41 79 407 72 58 |
Sileia Urech Phone: +41 79 935 81 48 |
|
Nathalie Altermatt Phone: +41 79 771 05 25 |
Lorena Corfas Phone: +41 79 568 24 95 |
|
Simon Goldsborough Phone: +44 797 32 72 915 |
Karsten Kleine Phone: +41 79 461 86 83 |
|
Nina Mählitz Phone: +41 79 327 54 74 |
Kirti Pandey Phone: +49 172 6367262 |
|
Yvette Petillon Phone: +41 79 961 92 50 |
Dr Rebekka Schnell Phone: +41 79 205 27 03 |
Roche Investor Relations
|
Dr Bruno Eschli Phone: +41 61 68-75284 e-mail: bruno.eschli@roche.com |
Dr Sabine Borngräber Phone: +41 61 68-88027 e-mail: sabine.borngraeber@roche.com |
|
Dr Birgit Masjost Phone: +41 61 68-84814 e-mail: birgit.masjost@roche.com |
Investor Relations North America
|
Loren Kalm Phone: +1 650 225 3217 e-mail: kalm.loren@gene.com |
Attachment
Nachrichten zu Roche Holding AG (Inhaberaktie)
|
17.01.25 |
Pluszeichen in Zürich: SPI nachmittags in der Gewinnzone (finanzen.ch) | |
|
17.01.25 |
Optimismus in Zürich: SPI steigt (finanzen.ch) | |
|
17.01.25 |
SPI-Papier Roche-Aktie: So viel Gewinn hätte ein Investment in Roche von vor einem Jahr abgeworfen (finanzen.ch) | |
|
17.01.25 |
Aufschläge in Zürich: SPI liegt zum Start im Plus (finanzen.ch) | |
|
16.01.25 |
Optimismus in Zürich: SPI beendet den Donnerstagshandel in der Gewinnzone (finanzen.ch) | |
|
16.01.25 |
Aufschläge in Zürich: Am Nachmittag Pluszeichen im SPI (finanzen.ch) | |
|
16.01.25 |
Freundlicher Handel: SPI liegt am Donnerstagmittag im Plus (finanzen.ch) | |
|
16.01.25 |
Gute Stimmung in Zürich: SPI beginnt Donnerstagshandel mit Gewinnen (finanzen.ch) |
Analysen zu Roche Holding AG (Inhaberaktie)
KI gefragt: Aktien für die Ewigkeit – Wall Street Live mit Tim Schäfer
In unserer heutigen Folge spricht Tim Schäfer im Interview mit David Kunz, COO der BX Swiss AG über eine Auswahl an Aktien, welche von einer künstlichen Intelligenz prognostiziert wurden. Diese Titel sind laut KI optimal für ein langfristiges Buy and Hold Portfolio.
Welche Meinung haben Tim Schäfer und David Kunz vom Portfolio und halten diese Titel langfristig stand? Diese und weitere Fragen beantwortet Tim Schäfer in der heutigen Ausgabe von Wall Street Live.
In unserem zweiwöchigen Format „Wall Street Live“ mit Tim Schäfer behandeln wir Topaktuelle Themen des Marktgeschehens.
👉🏽 https://bxplus.ch/wall-street-live-mit-tim-schaefer/
Inside Trading & Investment
Mini-Futures auf SMI
Aktien in diesem Artikel
| Roche Holding AG (Inhaberaktie) | 285.00 | -0.90% |
|
Meistgelesene Nachrichten
Börse aktuell - Live Ticker
SMI geht mit Gewinnen ins Wochenende -- DAX schliesst höher und knackt erstmals 20'900-Punkte-Marke -- Wall Street schlussendlich stärker -- Asiens Börsen letztlich uneinheitlichDer heimische Aktienmarkt zeigte sich vor dem Wochenende freundlich und überschritt zeitweise sogar die 12'000-Punkte-Marke. Der deutsche Leitindex setzte seine Rekordrally fort und knackte erstmals die 20'900 Zähler. Die US-Börsen notierten im Freitagshandel mit Gewinnen. Die Börsen in Fernost fanden am Freitag keine gemeinsame Richtung.
finanzen.net News
| Datum | Titel |
|---|---|
|
{{ARTIKEL.NEWS.HEAD.DATUM | date : "HH:mm" }}
|
{{ARTIKEL.NEWS.BODY.TITEL}} |